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Inflammation & Immune Activation

Kidney Drug Sevelamer May Reduce Gut Leakage During Acute HIV Infection

The phosphate-binding agent sevelamer can bind to bacterial toxins and reduce excessive immune activation in macaque monkeys with a simian virus similar to HIV, according to a report in the June 2 Journal of Clinical Investigation. A related study, however, failed to see a reduction in inflammation biomarkers in people with untreated HIV disease.

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CROI 2014: Researchers Discuss HIV, Aging, and Frailty

People living with HIV are at greater risk of geriatric syndromes such as frailty and difficulty with daily activities than HIV negative people of the same age -- and this can have a significant effect upon their quality of life as they age, according to several studies presented at the 14th Conference on Retroviruses and Opportunistic Infections (CROI 2014) last month in Boston.

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CROI 2014: Early Antiretroviral Therapy May Limit Gut Damage and Immune Activation

Starting antiretroviral therapy (ART) at the earliest stage of HIV infection can help prevent immune cell dysregulation that contributes to destruction of the gut lining and promotes systemic immune over-activation, according to a study presented at the Conference on Retroviruses and Opportunistic Infections (CROI 2014) last week in Boston.

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CROI 2014: Dapivirine Vaginal Ring Appears Safe and Effective in Tissue Study

Vaginal rings containing the experimental NNRTI dapivirine were well-tolerated and blocked HIV infection of cervical tissue samples, but rings containing maraviroc did not produce adequate drug concentrations, researchers reported at the 21st Conference on Retroviruses and Opportunistic Infections (CROI 2014) this month in Boston.

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HIV Triggers CD4 T-Cell Death via Inflammation

HIV infection sets off a vicious cycle of inflammation and cell death dubbed "pyroptosis" -- or fiery cell suicide -- according to a pair of recent reports from researchers at UCSF's Gladstone Institutes.

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