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Atripla Label Adds Drug Interactions with Hepatitis C Protease Inhibitors Boceprevir and Telaprevir

The U.S. Food and Drug Administration (FDA) announced this week that the product label information for Atripla -- the HIV single-tablet regimen containing efavirenz/tenofovir/emtricitabine -- has been updated to include information about drug-drug interactions with the hepatitis C virus protease inhibitors boceprevir (Victrelis) and telaprevir (Incivek or Incivo).

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NIH Halts HIV Vaccine Study Due to Lack of Effectiveness

 

The National Institutes of Institute of Allergy and Infectious Diseasesannounced this week that it will halt administration of an experimental HIV vaccine in the HVTN 505 trial, after an interim data analysis found that it neither prevented new HIV infections nor lowered viral load among people who did become infected.

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Study Suggests Why Adult Circumcision Helps Prevent HIV Infection

Removal of the foreskin reduces the presence of anaerobic bacteria, which enables the immune system maintain control of sexually transmitted pathogens such as HIV, according to a study from Uganda reported in the April 16, 2013, edition of the open-access online journal mBio, published by the American Society for Microbiology (ASM).

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Reformulated Tenofovir Gel Found Safe and Acceptable for Anal Sex

 

Men and women found a microbicide gel containing 1% tenofovir -- which has been shown to reduce the risk of HIV infection during vaginal sex -- to also be acceptable for anal use after it was reformulated to reduce the amount of an ingredient that led to irritation in an earlier study, according to a report in the April 3, 2013, edition of PLoS ONE.

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CROI 2013: Random Anal Biopsies Improve Detection of Pre-cancerous Lesions

Performing random anal biopsies increases the rate of diagnosis of high-grade squamous intraepithelial lesions (HSIL) during high-resolution anoscopy, researchers from Mt. Sinai School of Medicine in New York City reported at the recent 20th Conference on Retroviruses and Opportunistic Infections (CROI 2013).alt

Antiretroviral Therapy May Have Protective Effect on HIV+ Children's Hearts

Long-term use of combination antiretroviral therapy (ART) does not impair heart function in children and adolescents with perinatal HIV infection, and in fact appears to have a "cardioprotective" effect, according to a study published in the April 22, 2013, advance online edition of JAMA Pediatrics.

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CROI 2013: Gene Therapy Studies Show Potential for HIV Control without Drugs

Modified immune cells that make their own fusion inhibitors reduce levels of HIV-like virus and resisted infection in animal and test tube studies, researchers reported at the 20th Conference on Retroviruses and Opportunistic Infections (CROI 2013) last month in Atlanta.

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