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HIV Treatment

FDA Advisors Favor Approval of 4-in-1 Elvitegravir Quad Pill for HIV

On May 11, 2012, the Antiviral Drugs Advisory Committee of the U.S. Food and Drug Administration (FDA) recommended approval of Gilead Sciences' 4-in-1 once-daily single-tablet antiretroviral regimen known as the Quad. A final decision in expected by late summer.alt

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FDA Approves New Fosamprenavir Dose Regimen, Nevirapine Tablets for HIV+ Children

The U.S. Food and Drug Administration (FDA) has approved new dosing recommendations for use of fosamprenavir (Lexiva) oral suspension for children with HIV. The agency also approved a generic nevirapine tablet for use by HIV positive children in PEPFAR countries.alt

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CROI: HIV+ People with CD4 Counts Above 500 Match Life Expectancy of General Population

People with HIV who respond well to antiretroviral therapy (ART) and achieve undetectable viral load and a CD4 T-cell count above 500 cells/mm3 can have a mortality rate similar to that of HIV negative people, but this is not the case for those with 350-500 cells/mm3, according to a study presented at the 19th Conference on Retroviruses and Opportunistic Infections (CROI 2012) last month in Seattle.alt

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HIV Gene Therapy Shows Long-term Safety and Activity after 11 Years

Genetically modified T-cells engineered to attack HIV were still present and showed continued antiviral activity, with no serious adverse outcomes, 11 years after administration, according to log-term follow-up data from 3 studies described in the latest issue of Science Translational Medicine.alt

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Novel HIV Integrase Inhibitor Dolutegravir Matches Raltegravir in Phase 3 Study

ViiV Healthcare and Japan's Shionogi announced this week that its experimental integrase inhibitor dolutegravir (formerly S/GSK1349572) worked as well as the sole approved integrase inhibitor, raltegravir (Isentress), for people with HIV starting antiretroviral treatment for the first time.alt

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CROI: The Long and Winding Road to a Cure for HIV

No one ever thought finding a cure for AIDS would be easy. Medical research is rarely clear-cut, and an HIV cure breakthrough will be a monumental achievement. Yet at this year's Conference on Retroviruses and Opportunistic Infections (CROI 2012), there were significant signs that AIDS cure research is on its way up a long and winding road at the foot of a very big hill. While a functional cure (ability to control HIV without antiretroviral treatment) or total HIV eradication (known as sterilizing cure) may be a steep climb, advances in this field may improve the current state of HIV treatment.alt

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CROI: How Detrimental Is Low but Detectable HIV Viral Load?

Having low but detectable viral load is associated with problems including cardiovascular disease and cancer in people with HIV, researchers reported at the 19th Conference on Retroviruses and Opportunistic Infections (CROI 2012) last month in Seattle.alt

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